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Completely, our data supply evidence for your likely of combining CX-5461 and PARPi for bettering the procedure of HR-deficient HGSOC. We show that CX-5461 enhances the synthetic lethal interaction of PARPi with HRD and clearly present that CX-5461 has a different system of motion to PARPi. Importantly, we characterised BRCA-mutated and MYC targets